SphK1&2-IN-1

Modify Date: 2026-03-27 12:50:32

SphK1&2-IN-1 Structure
SphK1&2-IN-1 structure
Common Name SphK1&2-IN-1
CAS Number 1415662-57-5 Molecular Weight 290.34
Density N/A Boiling Point N/A
Molecular Formula C14H14N2O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SphK1&2-IN-1


SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)

 SphK1&2-IN-1 Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].
Related Catalog
Target

SphK1

SphK2

In Vitro SphK1&2-IN-1 (化合物 40) (10 μM) 对 SphK1 和 SphK2 的抑制率分别为 14.3% 和 26.5%[1]。 SphK1&2-IN-1 (化合物 W4) (1-100 μM) 具有良好的热稳定性[1]。
References

[1]. Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67.  

[2]. Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511.  

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Molecular Formula C14H14N2O3S
Molecular Weight 290.34
InChIKey SMRXKMFZQYOXSX-GQCTYLIASA-N
SMILES COc1ccc(C=CC(=O)Nc2nccs2)cc1OC
Storage condition -20°C

 SphK1&2-IN-1Bioassay

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This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Haemostatic activity in human plasma assessed as change in rate of activated partial ...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179006
Name: Haemostatic activity in human plasma assessed as change in rate of thrombin time at 1...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179007
Name: Haemostatic activity in human plasma assessed as change in rate of thrombin time at 5...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179008
Name: Haemostatic activity in human plasma assessed as change in rate of thrombin time at 1...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179009
Name: Haemostatic activity in human plasma assessed as change in rate of activated partial ...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179002
Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262
Name: Haemostatic activity in human plasma assessed as change in rate of activated partial ...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179003
Name: Haemostatic activity in human plasma assessed as change in rate of activated partial ...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179004
Name: Inhibition of human recombinant Sphk2 at 10 uM after 60 mins by ADP2 fluorescence int...
Source: ChEMBL
Target: Sphingosine kinase 2
External Id: CHEMBL3373185
Name: Haemostatic activity in human plasma assessed as change in rate of activated partial ...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179005
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 SphK1&2-IN-1 | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)?
A: The English name of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E) is 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E).
Q: What is the InChIKey of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)?
A: InChIKey of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E) is SMRXKMFZQYOXSX-GQCTYLIASA-N.
Q: What are the storage conditions for 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)?
A: Storage conditions for 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E): -20°C.
Q: What is the molecular weight of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)?
A: Molecular weight of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E) is 290.34.
Q: What is the CAS number of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)?
A: CAS number of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E) is 1415662-57-5.
Q: What is the SMILES notation of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)?
A: SMILES notation of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E) is COc1ccc(C=CC(=O)Nc2nccs2)cc1OC.
Q: What are the uses of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)?
A: Main uses of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E): SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].
Q: What is the molecular formula of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)?
A: Molecular formula of 2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E) is C14H14N2O3S.
Q: What is the Chinese name of 1415662-57-5?
A: Chinese name of 1415662-57-5 is WAY-272077.

 SphK1&2-IN-1factory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
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