SphK1&2-IN-1

Modify Date: 2026-03-27 12:50:32

SphK1&2-IN-1 structure	Common Name	SphK1&2-IN-1
	CAS Number	1415662-57-5	Molecular Weight	290.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₄N₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SphK1&2-IN-1

SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].

Name	2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)

Description	SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> SPHK
Target	SphK1 SphK2
In Vitro	SphK1&2-IN-1 (化合物 40) (10 μM) 对 SphK1 和 SphK2 的抑制率分别为 14.3% 和 26.5%[1]。 SphK1&2-IN-1 (化合物 W4) (1-100 μM) 具有良好的热稳定性[1]。
References	[1]. Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67. [2]. Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511.

Molecular Formula	C₁₄H₁₄N₂O₃S
Molecular Weight	290.34
InChIKey	SMRXKMFZQYOXSX-GQCTYLIASA-N
SMILES	COc1ccc(C=CC(=O)Nc2nccs2)cc1OC
Storage condition	-20°C

Name: Haemostatic activity in human plasma assessed as change in rate of activated partial ...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179006

Name: Haemostatic activity in human plasma assessed as change in rate of thrombin time at 1...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179007

Name: Haemostatic activity in human plasma assessed as change in rate of thrombin time at 5...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179008

Name: Haemostatic activity in human plasma assessed as change in rate of thrombin time at 1...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179009

Name: Haemostatic activity in human plasma assessed as change in rate of activated partial ...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179002

Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262

Name: Haemostatic activity in human plasma assessed as change in rate of activated partial ...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179003

Name: Haemostatic activity in human plasma assessed as change in rate of activated partial ...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179004

Name: Inhibition of human recombinant Sphk2 at 10 uM after 60 mins by ADP2 fluorescence int...
Source: ChEMBL
Target: Sphingosine kinase 2
External Id: CHEMBL3373185

Name: Haemostatic activity in human plasma assessed as change in rate of activated partial ...
Source: ChEMBL
Target: Plasma
External Id: CHEMBL4179005

Total 20, Current Page 1 of 2

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

SphK1&2-IN-1

Use of SphK1&2-IN-1

Names

SphK1&2-IN-1 Biological Activity

Chemical & Physical Properties

SphK1&2-IN-1Bioassay

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.