Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

192323-14-1

192323-14-1 structure

192323-14-1 structure

Name: hACC2-IN-1
Chemical Name: hACC2-IN-1
CAS Number: 192323-14-1
Molecular Formula: C₂₃H₃₂N₂O₄S
Molecular Weight: 432.58
Catalog: Signaling Pathways Metabolic Enzyme/Protease Acetyl-CoA Carboxylase
Create Date: 2022-10-07 12:11:15
Modify Date: 2024-04-07 06:08:49
hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research[1].

Name	hACC2-IN-1

Description	hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Acetyl-CoA Carboxylase
Target	hACC2:2.5 μM (IC50)
In Vitro	ACC2 isoform, presents on the mitochondrial surface, inhibits carnitine palmitoyl transferase 1 (CPT-1) and converts acetyl-CoA into malonylCoA for de novo lipogenesis in the cytosol[1]. ACCs inhibition will change cellular substrate and favour lipid oxidation, thus preventing deleterious lipids from accumulating in oxidative tissue such as muscle, heart and liver[1]. hACC2-IN-1 shows good potency against the human ACC2 (hACC2) enzyme[1].
References	[1]. Bengtsson C, et al. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem. 2011 May 15;19(10):3039-53.

Molecular Formula	C₂₃H₃₂N₂O₄S
Molecular Weight	432.58

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.