hACC2-IN-1

Modify Date: 2024-04-07 06:08:49

hACC2-IN-1 structure	Common Name	hACC2-IN-1
	CAS Number	192323-14-1	Molecular Weight	432.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₂N₂O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of hACC2-IN-1

hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research[1].

Name	hACC2-IN-1

Description	hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Acetyl-CoA Carboxylase
Target	hACC2:2.5 μM (IC50)
In Vitro	ACC2 isoform, presents on the mitochondrial surface, inhibits carnitine palmitoyl transferase 1 (CPT-1) and converts acetyl-CoA into malonylCoA for de novo lipogenesis in the cytosol[1]. ACCs inhibition will change cellular substrate and favour lipid oxidation, thus preventing deleterious lipids from accumulating in oxidative tissue such as muscle, heart and liver[1]. hACC2-IN-1 shows good potency against the human ACC2 (hACC2) enzyme[1].
References	[1]. Bengtsson C, et al. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem. 2011 May 15;19(10):3039-53.

Molecular Formula	C₂₃H₃₂N₂O₄S
Molecular Weight	432.58