2387510-88-3
2387510-88-3 structure
- Name: OD36 hydrochloride
- Chemical Name: OD36 hydrochloride
- CAS Number: 2387510-88-3
- Molecular Formula: C16H16Cl2N4O2
- Molecular Weight: 367.23
- Catalog: Signaling Pathways Apoptosis RIP kinase
- Create Date: 2022-10-11 20:25:04
- Modify Date: 2024-01-12 19:01:32
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OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 hydrochloride is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 hydrochloride shows ALK2-directed activity with KDs of 37 nM[1][2].
| Name | OD36 hydrochloride |
|---|
| Description | OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 hydrochloride is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 hydrochloride shows ALK2-directed activity with KDs of 37 nM[1][2]. |
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| Related Catalog | |
| Target |
RIPK2:5.3 nM (IC50) ACVR1:37 nM (Kd) ACVR1:47 nM (IC50) ALK2 R206H:22 nM (IC50) |
| In Vitro | OD36 also inhibits ALK2 and ALK2 R206H with IC50s of 47 and 22 nM, respevtively[1]. OD36 shows activity against ALK1 with a KD of 90 nM[2]. OD36 potently antagonize mutant ALK2 signaling and osteogenic differentiation[2]. OD36 (0.1-1 μM; 24 h) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5 in KS483 cells[2]. Preincubation of fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs) with OD36 (0.5 μM) completely prevents the activation of Smad1/5 and gene targets ID-1 and ID-3 in response to activin A[2]. Western Blot Analysis[2] Cell Line: KS483 cells Concentration: 0.1, 0.2, and 1 μM Incubation Time: 24 h Result: Inhibited BMP-6 induced p-Smad1/5. |
| In Vivo | OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model[3]. Animal Model: C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis[3] Dosage: 6.25 mg/kg Administration: Intraperitoneal injection, 30 min prior to MDP Result: Inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression. |
| References |
| Molecular Formula | C16H16Cl2N4O2 |
|---|---|
| Molecular Weight | 367.23 |