1186660-06-9

1186660-06-9 structure

Name: PKM2 activator 2
Chemical Name: PKM2 activator 2
CAS Number: 1186660-06-9
Molecular Formula: C₂₀H₁₈F₂N₂O₄S₂
Molecular Weight: 452.49
Catalog: Research Areas Cancer
Create Date: 2022-10-12 12:55:46
Modify Date: 2024-01-18 15:49:16
PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells[1].

Name	PKM2 activator 2

Description	PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells[1].
Related Catalog	Research Areas >> Cancer
Target	PKM2:66 nM (EC50)
In Vitro	PKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines [1]. PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC50 value of 66 nM in the luciferase-coupled assay[1].
References	[1]. Boxer MB, et al. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010 Feb 11;53(3):1048-55.

Molecular Formula	C₂₀H₁₈F₂N₂O₄S₂
Molecular Weight	452.49