PKM2 activator 2
Modify Date: 2024-01-18 15:49:16
PKM2 activator 2 structure
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Common Name | PKM2 activator 2 | ||
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| CAS Number | 1186660-06-9 | Molecular Weight | 452.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H18F2N2O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PKM2 activator 2PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells[1]. |
| Name | PKM2 activator 2 |
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| Description | PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells[1]. |
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| Related Catalog | |
| Target |
PKM2:66 nM (EC50) |
| In Vitro | PKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines [1]. PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC50 value of 66 nM in the luciferase-coupled assay[1]. |
| References |
| Molecular Formula | C20H18F2N2O4S2 |
|---|---|
| Molecular Weight | 452.49 |