1111078-63-7
1111078-63-7 structure
- Name: SCD1-IN-1
- Chemical Name: SCD1-IN-1
- CAS Number: 1111078-63-7
- Molecular Formula: C20H20F3NO4
- Molecular Weight: 395.37
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Stearoyl-CoA Desaturase (SCD)
- Create Date: 2022-10-07 18:03:20
- Modify Date: 2024-01-02 17:59:21
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SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition[1].
| Name | SCD1-IN-1 |
|---|
| Description | SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition[1]. |
|---|---|
| Related Catalog | |
| Target |
SCD1[1]. |
| In Vitro | SCD1-IN-1 (compound I, 6 days) inhibits the SCD1 enzyme in intact human cells, with an IC50 value of 6.8 nM[1]. |
| In Vivo | SCD1-IN-1 (compound I, 1.5% w/v, 25 μL, applied to surfaces of ears) reduces in cholesterol ester (CE) and wax ester (WE) production in hamster ear model[1]. Animal Model: Hamster ear model[1] Dosage: 1.5% in a vehicle of propylene glycol/transcutanol/ethanol 20/20/60, w/v, 25 μL. Administration: Applied to ~3 cm2 of the ventral surfaces of both the right and left ears, twice daily for 2 weeks. Result: Resulted in a 62% reduction in CE and an 82% reduction in WE, a mechanism biomarker for sebum production in the hamster model, and a reduction in sebaceous gland size. |
| References |
[1]. Li Jin, et al. Phenoxy-pyrrolidine derivative and its use and compositions Patent. WO2009019566. |
| Molecular Formula | C20H20F3NO4 |
|---|---|
| Molecular Weight | 395.37 |