420809-56-9
420809-56-9 structure
- Name: α-Glucosidase-IN-20
- Chemical Name: α-Glucosidase-IN-20
- CAS Number: 420809-56-9
- Molecular Formula: C23H21NOS
- Molecular Weight: 359.48
- Catalog: Research Areas Metabolic Disease
- Create Date: 2022-11-02 11:55:25
- Modify Date: 2024-04-03 17:02:35
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α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity[1].
| Name | α-Glucosidase-IN-20 |
|---|
| Description | α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active α-glucosidase inhibitor with an IC50 of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity[1]. |
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| Related Catalog | |
| In Vivo | α-Glucosidase-IN-20 (Compound 3B; 10 and 20 mg/kg; p.o.; daily, for 4 weeks) has anti-diabetic activity in Streptozocin (HY-13753)-induced diabetic rats[1]. α-Glucosidase-IN-20 (10 and 20 mg/kg; p.o.; once) significantly decreases the serum glucose level after the administration of glucose (3 g/kg, oral) in rats[1]. α-Glucosidase-IN-20 (2000 mg/kg; p.o.; daily, for 2 weeks) demonstrates no mortality in mice[1]. Animal Model: Male Wistar albino rats (170-200 g), Streptozotocin-induced diabetes model[1] Dosage: 10 and 20 mg/kg Administration: Oral administration; daily, for 4 weeks Result: Decreased the level of blood glucose, reversed Streptozocin-induced body weight loss. Showed antihyperlipidemic effects on Streptozotocin-induced diabetes, reduced to a significant level of serum biomarkers. |
| References |
| Molecular Formula | C23H21NOS |
|---|---|
| Molecular Weight | 359.48 |