161187-57-1
161187-57-1 structure
- Name: α-Glucosidase-IN-23
- Chemical Name: α-Glucosidase-IN-23
- CAS Number: 161187-57-1
- Molecular Formula: C20H23NO6
- Molecular Weight: 373.40
- Catalog: Research Areas Metabolic Disease
- Create Date: 2023-06-20 12:52:55
- Modify Date: 2024-01-16 16:54:00
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α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes[1].
| Name | α-Glucosidase-IN-23 |
|---|
| Description | α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes[1]. |
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| Related Catalog | |
| Target |
IC50: 4.48 μM (a-glucosidase)[1]. |
| In Vitro | α-Glucosidase-IN-23 (compound 8b) (1 μM) 具有显著的抗糖尿病作用[1]。 α-Glucosidase-IN-23 减少 β 细胞和肌肉细胞中的 ROS[1]。 α-Glucosidase-IN-23 通过抑制 a-glucosidase 降低血糖，IC50 值为 4.48 μM[1]。 Cell Proliferation Assay[1] Cell Line: INS-1 Cells Concentration: 1 μM Incubation Time: Result: Stimulated the growth of INS-1 cells in a dose-codependent approach. Apoptosis Analysis[1] Cell Line: INS-1 Cells Concentration: 1 μM Incubation Time: Result: Restored the viability of INS-1 cells by about five times from apoptosis and eight times from necrosis. |
| In Vivo | α-Glucosidase-IN-23（口服；0.2 mmol/kg/天）仅抑制小鼠体内的 α-葡萄糖苷酶[1]。 Animal Model: Mice[1] Dosage: 0.2 mmol/kg Administration: Oral; 0.2 mmol/kg/day Result: Cmax (nmol/mL) Tmax (h) T1/2(h) AUC (ng/h/mL) 10.11 ± 1.17 0.8 ± 0.0 1.90 ± 1.04 36.7 ± 2.23 |
| References |
| Molecular Formula | C20H23NO6 |
|---|---|
| Molecular Weight | 373.40 |