296793-09-4

296793-09-4 structure

296793-09-4 structure

Name: SIRT2-IN-10
Chemical Name: SIRT2-IN-10
CAS Number: 296793-09-4
Molecular Formula: C₂₈H₂₁N₅OS
Molecular Weight: 475.56
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2022-11-17 08:38:10
Modify Date: 2024-02-20 10:08:25
SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC50 of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease[1].

Name	SIRT2-IN-10

Description	SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC50 of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Research Areas >> Neurological Disease
Target	SIRT2[1]
In Vitro	SIRT2-IN-10 (Compound 12) (0-50 μM; 72 h) inhibits the proliferation of MCF-7 cells in a concentration-dependent manner[1]. SIRT2-IN-10 (6.25-50 μM; 6 h) increased the acetylation level of α-tubulin in a concentration-dependent manner in MCF-7 cells[1]. Cell Proliferation Assay[1] Cell Line: MCF-7 cells Concentration: 0, 0.6, 1.8, 5.5, 16.6 and 50.0 μM Incubation Time: 72 h Result: Inhibited the proliferation in a concentration-dependent manner. Western Blot Analysis[1] Cell Line: MCF-7 cells Concentration: 6.25, 12.5, 25 and 50 μM Incubation Time: 6 h Result: Dose-dependently increased the acetylation level of α-tubulin.
References	[1]. Shengyong Yang, et al. The purposes of 5H- [1,2,4] triazine [5,6-b] indole derivatives of 3 substitutions. Patent CN108309982A.

Molecular Formula	C₂₈H₂₁N₅OS
Molecular Weight	475.56