296793-09-4
296793-09-4 structure
- Name: SIRT2-IN-10
- Chemical Name: SIRT2-IN-10
- CAS Number: 296793-09-4
- Molecular Formula: C28H21N5OS
- Molecular Weight: 475.56
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2022-11-17 08:38:10
- Modify Date: 2024-02-20 10:08:25
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SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC50 of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease[1].
| Name | SIRT2-IN-10 |
|---|
| Description | SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC50 of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease[1]. |
|---|---|
| Related Catalog | |
| Target |
SIRT2[1] |
| In Vitro | SIRT2-IN-10 (Compound 12) (0-50 μM; 72 h) inhibits the proliferation of MCF-7 cells in a concentration-dependent manner[1]. SIRT2-IN-10 (6.25-50 μM; 6 h) increased the acetylation level of α-tubulin in a concentration-dependent manner in MCF-7 cells[1]. Cell Proliferation Assay[1] Cell Line: MCF-7 cells Concentration: 0, 0.6, 1.8, 5.5, 16.6 and 50.0 μM Incubation Time: 72 h Result: Inhibited the proliferation in a concentration-dependent manner. Western Blot Analysis[1] Cell Line: MCF-7 cells Concentration: 6.25, 12.5, 25 and 50 μM Incubation Time: 6 h Result: Dose-dependently increased the acetylation level of α-tubulin. |
| References |
| Molecular Formula | C28H21N5OS |
|---|---|
| Molecular Weight | 475.56 |