1005095-06-6
1005095-06-6 structure
- Name: SIRT2-IN-11
- Chemical Name: WAY-324197
- CAS Number: 1005095-06-6
- Molecular Formula: C21H22N2O
- Molecular Weight: 318.4
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2022-11-30 10:54:49
- Modify Date: 2024-04-06 13:50:21
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SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1].
| Name | WAY-324197 |
|---|---|
| Synonyms | 7,10-Methanophenanthridine-2-carboxamide, 5,6,6a,7,8,9,10,10a-octahydro-6-phenyl- |
| Description | SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1]. |
|---|---|
| Related Catalog | |
| Target |
SIRT2:18.5 μM (IC50) SIRT1:118.4 μM (IC50) |
| In Vitro | SIRT2-IN-11 (0-1000 μM) shows inhibitory effect of SIRT2-dependent deacetylation of MAL with an IC50 value of 18.5 μM[1]. SIRT2-IN-11 (0-1000 μM) weakly inhibits SIRT1 with an IC50 value of 118.4 μM[1]. SIRT2-IN-11 (0-20 μM; 8 h) induces cell apoptosis of lung cancer cells[1]. SIRT2-IN-11 (20 μM; 6 h) increases p53 acetylation and expression levels of Cp53 target genes CDKN1A, PUMA and NOXA[1]. RT-PCR[1] Cell Line: NSCLC cell lines Concentration: 20 μM Incubation Time: 6 hours Result: Increased the expression of CDKN1A, PUMA and NOXA. Apoptosis Analysis[1] Cell Line: A549 cell line Concentration: 0, 0.5, 1, 5, 10 and 20 μM Incubation Time: 24 hours Result: Mildly increased apoptosis of A549 cells, but when combined treatment with etoposide caused a marked increase in apoptosis. |
| References |
| Molecular Formula | C21H22N2O |
|---|---|
| Molecular Weight | 318.4 |