438474-67-0

438474-67-0 structure

Name: Antitrypanosomal agent 9
Chemical Name: WAY-325462
CAS Number: 438474-67-0
Molecular Formula: C₂₂H₂₇NO₃
Molecular Weight: 353.45
Catalog: Research Areas Infection
Create Date: 2022-11-28 19:47:51
Modify Date: 2024-04-03 15:53:49
Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1].

Name	WAY-325462
Synonyms	Methanone, [4-[(4-ethoxyphenoxy)methyl]phenyl](3-methyl-1-piperidinyl)- {4-[(4-Ethoxyphenoxy)methyl]phenyl}(3-methyl-1-piperidinyl)methanone

Description	Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1].
Related Catalog	Research Areas >> Infection
In Vitro	Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 ± 0.076, 107 ± 34.5, 35.7 ± 6.22, and 22.3 ± 1.06 μM, respectively[1]. Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 ± 94.2 μM[1].
References	[1]. Manos-Turvey Alexandra, et al. Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. Med Chem Commun. 2015, 6(3), 403–406.