Antitrypanosomal agent 9

Modify Date: 2024-04-03 15:53:49

Antitrypanosomal agent 9 Structure
Antitrypanosomal agent 9 structure
Common Name Antitrypanosomal agent 9
CAS Number 438474-67-0 Molecular Weight 353.45
Density 1.1±0.1 g/cm3 Boiling Point 521.5±35.0 °C at 760 mmHg
Molecular Formula C22H27NO3 Melting Point N/A
MSDS N/A Flash Point 269.2±25.9 °C

 Use of Antitrypanosomal agent 9


Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1].

 Names

Name WAY-325462
Synonym More Synonyms

 Antitrypanosomal agent 9 Biological Activity

Description Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1].
Related Catalog
In Vitro Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 ± 0.076, 107 ± 34.5, 35.7 ± 6.22, and 22.3 ± 1.06 μM, respectively[1]. Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 ± 94.2 μM[1].
References

[1]. Manos-Turvey Alexandra, et al. Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. Med Chem Commun. 2015, 6(3), 403–406.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 521.5±35.0 °C at 760 mmHg
Molecular Formula C22H27NO3
Molecular Weight 353.45
Flash Point 269.2±25.9 °C
Exact Mass 353.199097
LogP 4.00
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.560

 Synonyms

Methanone, [4-[(4-ethoxyphenoxy)methyl]phenyl](3-methyl-1-piperidinyl)-
{4-[(4-Ethoxyphenoxy)methyl]phenyl}(3-methyl-1-piperidinyl)methanone
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