110121-11-4
110121-11-4 structure
- Name: [Des-His1,Glu9] Glucagon
- Chemical Name: [Des-His1,Glu9] Glucagon
- CAS Number: 110121-11-4
- Molecular Formula: C148H220N40O48S
- Molecular Weight: 3359.63
- Catalog: Research Areas Metabolic Disease
- Create Date: 2022-11-30 17:17:44
- Modify Date: 2024-01-30 10:43:55
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[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes[1].
| Name | [Des-His1,Glu9] Glucagon |
|---|
| Description | [Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes[1]. |
|---|---|
| Related Catalog | |
| Target |
Glucagon Receptor[1] |
| In Vitro | [Des-His1,Glu9] Glucagon (1 pM-100 μM) does not activate membrane-bound adenylate cyclase up to a concentration of 2×10-4 molar in the cAMP assay on isolated rat liver membranes (from male Sprague Dawley rats)[1]. |
| In Vivo | [Des-His1,Glu9] Glucagon (3.6-4.0 μg/kg for rabbits, 1 mg/kg for rats; i.v.; single dosage) suppresses hyperglycemic effects in rabbits and rats[1]. Animal Model: New Zealand rabbits (2.8-3.8 kg; fasted for 18 hours)[1] Dosage: 3.6-4.0 μg/kg Administration: i.v.; single dosage Result: Suppressed hyperglycemic response of glucagon. Animal Model: Male Wistar rats weighing [350-400 mg; hyperglycemia induced by i.p. injection of 65 mg/kg Streptozotocin (HY-13753)][1] Dosage: 1 mg/kg Administration: Intravenously administration through the tail vein; single dosage Result: Decreased blood glucose rapidly, and reduced hyperglycemic effect by 70% within 5 min. |
| Molecular Formula | C148H220N40O48S |
|---|---|
| Molecular Weight | 3359.63 |