[Des-His1,Glu9] Glucagon

Modify Date: 2024-01-30 10:43:55

[Des-His1,Glu9] Glucagon structure	Common Name	[Des-His1,Glu9] Glucagon
	CAS Number	110121-11-4	Molecular Weight	3359.63
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄₈H₂₂₀N₄₀O₄₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of [Des-His1,Glu9] Glucagon

[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes[1].

Name	[Des-His1,Glu9] Glucagon

Description	[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	Glucagon Receptor[1]
In Vitro	[Des-His1,Glu9] Glucagon (1 pM-100 μM) does not activate membrane-bound adenylate cyclase up to a concentration of 2×10-4 molar in the cAMP assay on isolated rat liver membranes (from male Sprague Dawley rats)[1].
In Vivo	[Des-His1,Glu9] Glucagon (3.6-4.0 μg/kg for rabbits, 1 mg/kg for rats; i.v.; single dosage) suppresses hyperglycemic effects in rabbits and rats[1]. Animal Model: New Zealand rabbits (2.8-3.8 kg; fasted for 18 hours)[1] Dosage: 3.6-4.0 μg/kg Administration: i.v.; single dosage Result: Suppressed hyperglycemic response of glucagon. Animal Model: Male Wistar rats weighing [350-400 mg; hyperglycemia induced by i.p. injection of 65 mg/kg Streptozotocin (HY-13753)][1] Dosage: 1 mg/kg Administration: Intravenously administration through the tail vein; single dosage Result: Decreased blood glucose rapidly, and reduced hyperglycemic effect by 70% within 5 min.

Molecular Formula	C₁₄₈H₂₂₀N₄₀O₄₈S
Molecular Weight	3359.63

[Des-His1,Glu9] Glucagon

Use of [Des-His1,Glu9] Glucagon

Names

[Des-His1,Glu9] Glucagon Biological Activity

Chemical & Physical Properties