2705402-91-9
2705402-91-9 structure
- Name: N-Desmethylclozapine-d8 hydrochloride
- Chemical Name: N-Desmethylclozapine-d8 hydrochloride
- CAS Number: 2705402-91-9
- Molecular Formula: C17H10D8Cl2N4
- Molecular Weight: 357.31
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2023-01-16 22:35:48
- Modify Date: 2023-01-16 22:35:48
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Desmethylclozapine-d8 (Norclozapine-d8) hydrochloride is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic drug Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].
| Name | N-Desmethylclozapine-d8 hydrochloride |
|---|
| Description | Desmethylclozapine-d8 (Norclozapine-d8) hydrochloride is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic drug Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3]. |
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| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| Molecular Formula | C17H10D8Cl2N4 |
|---|---|
| Molecular Weight | 357.31 |