2126874-77-7
2126874-77-7 structure
- Name: CYP4A11/CYP4F2-IN-2
- Chemical Name: CYP4A11/CYP4F2-IN-2
- CAS Number: 2126874-77-7
- Molecular Formula: C16H20N4O2
- Molecular Weight: 300.36
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2023-01-17 16:24:00
- Modify Date: 2024-04-08 20:17:33
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CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 has potential for the research of renal diseases[1].
| Name | CYP4A11/CYP4F2-IN-2 |
|---|
| Description | CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 has potential for the research of renal diseases[1]. |
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| Related Catalog | |
| Target |
CYP4A11:140 nM (IC50) CYP4F2:40 nM (IC50) |
| In Vitro | CYP4A11/CYP4F2-IN-2 (compound 11c) inhibits 20-Hydroxyeicosatetraenoic acid (20-HETE) production from arachidonic acid in human renal microsomes, with an IC50 of 29 nM[1]. |
| In Vivo | CYP4A11/CYP4F2-IN-2 (compound 11c) (0.03-1 mg/kg; a single p.o.) inhibits renal 20-HETE production of rats in a dose-dependent manner[1]. CYP4A11/CYP4F2-IN-2 (0.5 mg/kg; i.v.) exhibits low CL (1430 mL/h/kg), moderate Vdss(763 mL/kg), and short T1/2 (0.424 h) in mice[1]. CYP4A11/CYP4F2-IN-2 (1 mg/kg; i.v.) exhibits low CL (226 mL/h/kg), moderate Vdss(839 mL/kg), and T1/2 (3.01 h) in SD rats[1]. CYP4A11/CYP4F2-IN-2 (1 mg/kg; p.o.) exhibits Cmax (623 ng/mL), T1/2 (3.03 h), and high bioavailability (97.7%) in SD rats[1]. |
| References |
| Molecular Formula | C16H20N4O2 |
|---|---|
| Molecular Weight | 300.36 |