1026652-90-3

1026652-90-3 structure

Name: Xanthine oxidoreductase-IN-5
Chemical Name: Xanthine oxidoreductase-IN-5
CAS Number: 1026652-90-3
Molecular Formula: C₁₇H₁₇N₅O₂
Molecular Weight: 323.35
Catalog: Signaling Pathways Metabolic Enzyme/Protease Xanthine Oxidase
Create Date: 2023-01-15 03:35:18
Modify Date: 2024-04-06 09:15:25
Xanthine oxidoreductase-IN-5 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 55 nM. Xanthine oxidoreductase-IN-5 can be used for the research of acute hyperuricemia[1].

Name	Xanthine oxidoreductase-IN-5

Description	Xanthine oxidoreductase-IN-5 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 55 nM. Xanthine oxidoreductase-IN-5 can be used for the research of acute hyperuricemia[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
Target	IC50: 55 nM (xanthine oxidoreductase)[1]
In Vivo	Xanthine oxidoreductase-IN-5 (化合物 IIIa) (5 mg/kg; 口服给药) 在给药后 5 h 显示出降低急性高尿酸血症小鼠尿酸的作用[1]。 Animal Model: ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine[1] Dosage: 5 mg/kg Administration: Suspended in 0.5% CMC-Na solution for intragastric administration Result: Showed a uric acid-lowering effect from 5 h after administration.
References	[1]. Peng W, et, al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947.

Molecular Formula	C₁₇H₁₇N₅O₂
Molecular Weight	323.35