1421830-13-8

1421830-13-8 structure

1421830-13-8 structure

Name: Lulizumab Pegol
Chemical Name: Lulizumab Pegol
CAS Number: 1421830-13-8
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Inflammation/Immunology
Create Date: 2023-03-16 12:18:01
Modify Date: 2024-04-05 18:00:11
Lulizumab pegol (BMS-931699) is an anti-CD28 antibody antagonist. Lulizumab pegol effectively inhibits T-cell proliferation and it can be used for the reseach of kidney transplantation and autoimmunity disease[1].

Name	Lulizumab Pegol

Description	Lulizumab pegol (BMS-931699) is an anti-CD28 antibody antagonist. Lulizumab pegol effectively inhibits T-cell proliferation and it can be used for the reseach of kidney transplantation and autoimmunity disease[1].
Related Catalog	Research Areas >> Inflammation/Immunology
In Vitro	BMS-931699 通过生物大分子相互作用分析系统显示出对 T 细胞增殖的 Kd 为 0.41 nM[1]。 BMS-931699 通过混合淋巴细胞反应 (MLR) 诱导的 T 细胞增殖的 EC50 为 2.9 nM 以及对全血中 CD28 受体占用 (RO) 的 EC50 为 4.4 nM[1]。
References	[1]. Yang Z, et al. Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699. J Pharmacol Exp Ther. 2015 Dec;355(3):506-15.

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