928892-60-8

928892-60-8 structure

Name: CB2R/FAAH modulator-1
Chemical Name: CB2R/FAAH modulator-1
CAS Number: 928892-60-8
Molecular Formula: C₂₄H₂₇NO₂
Molecular Weight: 361.48
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2023-03-31 12:16:56
Modify Date: 2024-04-09 16:51:33
CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with Kis of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production[1].

Name	CB2R/FAAH modulator-1

Description	CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with Kis of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH Signaling Pathways >> Neuronal Signaling >> FAAH Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB2R:14.8 nM (Ki) CB2R:123.6 nM (EC50) CB1R:241.3 nM (Ki) CB1R:489 nM (EC50)
In Vitro	CB2R/FAAH modulator-1 (化合物 13; 10 μM; 24 小时) 减少未刺激的单核细胞和巨噬细胞中促炎细胞因子 TNFα、IFN-γ、IL-1β 和 IL6 的产生[1] .
References	[1]. Francesca Intranuov, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250.

Molecular Formula	C₂₄H₂₇NO₂
Molecular Weight	361.48