2332841-83-3
2332841-83-3 structure
- Name: Pomstafib-2
- Chemical Name: Pomstafib-2
- CAS Number: 2332841-83-3
- Molecular Formula: C52H66N2O20P2
- Molecular Weight: 1101.03
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2023-04-15 16:10:29
- Modify Date: 2025-08-27 01:21:24
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Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis[1][2].
| Name | Pomstafib-2 |
|---|
| Description | Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Pomstafib-2 (compound 8) (0-10 µM; 4 h) decreases the expression of pSTAT5b in a dose-dependent manner in STAT5b-GFP-transfected K562 cells[1]. Pomstafib-2 (0, 10, 20, 40, 60, 80 µM; 48 h) induces apoptosis in a dose-dependent manner in STAT5-dependent K562 cells[1]. Western Blot Analysis[1] Cell Line: K562 leukaemia cells Concentration: 0, 0.3, 1, 3, 10 µM Incubation Time: 4 h Result: Decreased the expression of pSTAT5b in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: K562, MDA-MB-231 cells Concentration: 0, 10, 20, 40, 60, 80 µM Incubation Time: 48 h Result: Induced apoptosis in a dose-dependent manner in K562 cells, does not increased the apoptotic rate of STAT5-independent MDA-MB-231 cells. |
| References |
| Molecular Formula | C52H66N2O20P2 |
|---|---|
| Molecular Weight | 1101.03 |