Pomstafib-2
Modify Date: 2024-01-11 12:17:15
Pomstafib-2 structure
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Common Name | Pomstafib-2 | ||
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| CAS Number | 2332841-83-3 | Molecular Weight | 1101.03 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C52H66N2O20P2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Pomstafib-2Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis[1][2]. |
| Name | Pomstafib-2 |
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| Description | Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis[1][2]. |
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| Related Catalog | |
| In Vitro | Pomstafib-2 (compound 8) (0-10 µM; 4 h) decreases the expression of pSTAT5b in a dose-dependent manner in STAT5b-GFP-transfected K562 cells[1]. Pomstafib-2 (0, 10, 20, 40, 60, 80 µM; 48 h) induces apoptosis in a dose-dependent manner in STAT5-dependent K562 cells[1]. Western Blot Analysis[1] Cell Line: K562 leukaemia cells Concentration: 0, 0.3, 1, 3, 10 µM Incubation Time: 4 h Result: Decreased the expression of pSTAT5b in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: K562, MDA-MB-231 cells Concentration: 0, 10, 20, 40, 60, 80 µM Incubation Time: 48 h Result: Induced apoptosis in a dose-dependent manner in K562 cells, does not increased the apoptotic rate of STAT5-independent MDA-MB-231 cells. |
| References |
| Molecular Formula | C52H66N2O20P2 |
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| Molecular Weight | 1101.03 |