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2642181-22-2

2642181-22-2 structure
2642181-22-2 structure
  • Name: TP0597850
  • Chemical Name: TP0597850
  • CAS Number: 2642181-22-2
  • Molecular Formula: C41H57N9O13S
  • Molecular Weight: 916.01
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
  • Create Date: 2023-04-06 20:36:20
  • Modify Date: 2024-04-05 17:51:59
  • TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM). TP0597850 has a long MMP2 dissociation half-life (t1/2=265 min)[1].

Name TP0597850
Description TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM). TP0597850 has a long MMP2 dissociation half-life (t1/2=265 min)[1].
Related Catalog
Target

MMP2:0.22 nM (IC50)

MMP-12:250 nM (IC50)

MMP13:240 nM (IC50)

In Vitro TP0597850 (化合物 18) 在广谱 pH 值下表现出极高的化学稳定性[1]。 TP0597850 的抑制常数 Ki 值为 0.034 nM[1]。
References

[1]. Takeuchi T, et al. Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold. J Med Chem. 2023 Jan 12;66(1):822-836.  

Molecular Formula C41H57N9O13S
Molecular Weight 916.01