374101-64-1
374101-64-1 structure
- Name: NR2F1 agonist 1
- Chemical Name: NR2F1 agonist 1
- CAS Number: 374101-64-1
- Molecular Formula: C28H30N4OS
- Molecular Weight: 470.63
- Catalog: Research Areas Cancer
- Create Date: 2023-04-25 08:26:38
- Modify Date: 2024-07-16 11:44:27
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NR2F1 agonist 1, a nuclear receptor NR2F1 agonist, specifically activates dormancy programs in malignant cells. NR2F1 agonist 1 up-regulates NR2F1 and downstream target genes that regulate dormancy. NR2F1 agonist 1 induces neural crest-like and growth suppression in head and neck squamous cell carcinoma (HNSCC) via NR2F1 activation. NR2F1 agonist 1 inhibits tumor growth in a mouse primary tumor model[1].
| Name | NR2F1 agonist 1 |
|---|
| Description | NR2F1 agonist 1, a nuclear receptor NR2F1 agonist, specifically activates dormancy programs in malignant cells. NR2F1 agonist 1 up-regulates NR2F1 and downstream target genes that regulate dormancy. NR2F1 agonist 1 induces neural crest-like and growth suppression in head and neck squamous cell carcinoma (HNSCC) via NR2F1 activation. NR2F1 agonist 1 inhibits tumor growth in a mouse primary tumor model[1]. |
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| Related Catalog | |
| In Vitro | NR2F1 agonist 1（化合物 C26）（0.5 μM，1 μM；18 小时）显着诱导 D-HEp3 细胞中的荧光素酶表达[1]。 NR2F1 agonist 1（0.5 μM；7 天）显着下调磷酸肌醇 3-激酶 (PI3K) 信号通路[1]。 NR2F1 agonist 1（0.5 μM；7 天）显着上调 SOX9、RARβ 和 p27 的 mRNA 水平[1]。 NR2F1 agonist 1（0.5 μM；48 小时）在 D-HEp3 细胞中诱导细胞周期停滞在 G0/G1 期[1]。 |
| In Vivo | NR2F1 agonist 1（0.5 mg/kg/天；腹腔注射；3 周）抑制小鼠模型肺部的原发性肿瘤生长和转移性生长[1]。 Animal Model: BALB/c nu/nu mice bearing GFP-tagged T-HEp3 PDX cells[1] Dosage: 0.5 mg/kg/day Administration: Intraperitoneal injection; injected for 3 weeks or for 1 week followed by DMSO for 2 weeks Result: Did not induce apoptosis of proliferating primary tumor cells, but exhibited metastasis inhibitory effect against T-HEp3 cells. |
| References |
| Molecular Formula | C28H30N4OS |
|---|---|
| Molecular Weight | 470.63 |