2483831-91-8

2483831-91-8 structure

Name: α-Hydroxyglutaric acid-d4 disodium
Chemical Name: α-Hydroxyglutaric acid-d4 disodium
CAS Number: 2483831-91-8
Molecular Formula: C₅H₂D₄Na₂O₅
Molecular Weight: 196.10
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2023-04-29 12:54:11
Modify Date: 2024-01-17 17:49:17
α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

Name	α-Hydroxyglutaric acid-d4 disodium

Description	α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.

Molecular Formula	C₅H₂D₄Na₂O₅
Molecular Weight	196.10