2482467-23-0

2482467-23-0 structure

Name: α-Hydroxyglutaric acid-13C5 sodium
Chemical Name: α-Hydroxyglutaric acid-13C5 sodium
CAS Number: 2482467-23-0
Molecular Formula: ₁₃C₅H₈NaO₅
Molecular Weight: 176.07
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2023-04-29 19:28:38
Modify Date: 2024-01-25 09:21:53
α-Hydroxyglutaric acid-13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

Name	α-Hydroxyglutaric acid-13C5 sodium

Description	α-Hydroxyglutaric acid-13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.

Molecular Formula	₁₃C₅H₈NaO₅
Molecular Weight	176.07