2916433-81-1

2916433-81-1 structure

2916433-81-1 structure

Name: PROTAC GPX4 degrader-1
Chemical Name: PROTAC GPX4 degrader-1
CAS Number: 2916433-81-1
Molecular Formula: C₅₀H₅₇ClN₁₀O₁₀
Molecular Weight: 993.50
Catalog: Signaling Pathways Apoptosis Ferroptosis
Create Date: 2023-06-04 16:23:51
Modify Date: 2024-04-06 12:48:37
PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells[1].

Name	PROTAC GPX4 degrader-1

Description	PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Ferroptosis Signaling Pathways >> PROTAC >> PROTAC
In Vitro	PROTAC GPX4 degrader-1 (DC-2) has been found to induce GPX4 degradation and subsequent ferroptosis[1]. Western Blot Analysis[1]. Cell Line: HT1080 cells. Concentration: 0.003-1 μM. Incubation Time: 24 h. Result: Dose-dependently degraded GPX4 protein levels.
References	[1]. Han Wang, et al. Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells. Eur J Med Chem. 2023 Jun 5;254:115343.

Molecular Formula	C₅₀H₅₇ClN₁₀O₁₀
Molecular Weight	993.50