PROTAC GPX4 degrader-1

Modify Date: 2024-04-06 12:48:37

PROTAC GPX4 degrader-1 Structure
PROTAC GPX4 degrader-1 structure
 Common Name PROTAC GPX4 degrader-1
CAS Number 2916433-81-1 Molecular Weight 993.50
Density N/A Boiling Point N/A
Molecular Formula C50H57ClN10O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PROTAC GPX4 degrader-1


PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells[1].

 Names

Name PROTAC GPX4 degrader-1

 PROTAC GPX4 degrader-1 Biological Activity

Description PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells[1].
Related Catalog
In Vitro PROTAC GPX4 degrader-1 (DC-2) has been found to induce GPX4 degradation and subsequent ferroptosis[1]. Western Blot Analysis[1]. Cell Line: HT1080 cells. Concentration: 0.003-1 μM. Incubation Time: 24 h. Result: Dose-dependently degraded GPX4 protein levels.
References

[1]. Han Wang, et al. Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells. Eur J Med Chem. 2023 Jun 5;254:115343.  

 Chemical & Physical Properties

Molecular Formula C50H57ClN10O10
Molecular Weight 993.50
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Chemsrc provides PROTAC GPX4 degrader-1(CAS#:2916433-81-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of PROTAC GPX4 degrader-1 are included as well.>> amp version: PROTAC GPX4 degrader-1

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