240797-64-2
240797-64-2 structure
- Name: Tyrosinase-IN-11
- Chemical Name: Tyrosinase-IN-11
- CAS Number: 240797-64-2
- Molecular Formula: C15H14O5
- Molecular Weight: 274.27
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Tyrosinase
- Create Date: 2023-06-18 15:11:04
- Modify Date: 2024-03-12 21:16:05
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Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research[1].
| Name | Tyrosinase-IN-11 |
|---|
| Description | Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research[1]. |
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| Related Catalog | |
| In Vitro | Tyrosinase-IN-11 (化合物 11c; 0.1-2 μM; 72 小时) 以剂量依赖性方式降低 TYR 和 MiTF 的蛋白质水平[1]。 Tyrosinase-IN-11 (50 μM) 对人恶性黑色素瘤细胞 A375 和 B16F10 细胞具有轻微的细胞毒性[1]。 Western Blot Analysis[1] Cell Line: B16F10 cells Concentration: 0.1, 0.5, 1, 2 μM Incubation Time: 72 hours Result: Decreased the protein levels of both TYR and MiTF in a dose-dependent manner. |
| In Vivo | Tyrosinase-IN-11 (化合物 11c; 0.5, 1 mM; 局部给药; 每天在紫外线照射前，持续 2 周; 或在连续两周暴露于紫外线灯下，5 天/周，持续 2 周) 在豚鼠体内表现出强大的抗黑色素生成能力[1]。 Animal Model: Female guinea pigs (10 weeks old, 350-500 g) received ultraviolet exposure from a UV lamp[1] Dosage: 0.5, 1 mM Administration: Topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks Result: Inhibited the production of melanin in a dose-dependent manner. |
| References |
| Molecular Formula | C15H14O5 |
|---|---|
| Molecular Weight | 274.27 |