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2376999-19-6

2376999-19-6 structure

2376999-19-6 structure

Name: TYK2 JH2-IN-1-d3
Chemical Name: TYK2 JH2-IN-1-d3
CAS Number: 2376999-19-6
Molecular Formula: C₂₄H₂₁D₃FN₉O₃
Molecular Weight: 508.52
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2023-09-19 20:56:39
Modify Date: 2024-01-11 09:35:40
TYK2?JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC50=0.1 nM)[1].

Name	TYK2 JH2-IN-1-d3

Description	TYK2?JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC50=0.1 nM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK
Target	TYK2 JH2 domain[1]
References	[1]. Xiao Z, et al. Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations. Bioorg Med Chem Lett. 2023 Jul 15;91:129373.

Molecular Formula	C₂₄H₂₁D₃FN₉O₃
Molecular Weight	508.52

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