Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TIQ-A
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: TIQ-A
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

420849-22-5

420849-22-5 structure

420849-22-5 structure

Name: thieno(2,3-c)isoquinolin-5-one
Chemical Name: 4H-thieno[2,3-c]isoquinolin-5-one
CAS Number: 420849-22-5
Molecular Formula: C₁₁H₇NOS
Molecular Weight: 201.244
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2017-01-05 18:40:09
Modify Date: 2024-01-02 12:58:07
TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent[1].

Name	4H-thieno[2,3-c]isoquinolin-5-one
Synonyms	MFCD06407947 TIQ-A Thieno[2,3-c]isoquinolin-5-one PARP Inhibitor X,TIQ-A Thieno[2,3-c]isoquinolin-5(4H)-one thieno(2,3-c)isoquinolin-5-one

Description	TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	TNKS2:24 nM (IC50) PARP2:210 nM (IC50) PARP15:230 nM (IC50) PARP10:>10 μM (IC50) PARP14:>10 μM (IC50)
References	[1]. Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021 Dec 15;52:116511.

Density	1.4±0.1 g/cm3
Boiling Point	282.2±9.0 °C at 760 mmHg
Molecular Formula	C₁₁H₇NOS
Molecular Weight	201.244
Flash Point	124.5±18.7 °C
Exact Mass	201.024841
PSA	61.10000
LogP	3.16
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.675
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R20/21/22
RIDADR	NONH for all modes of transport