420849-22-5
420849-22-5 structure
- Name: thieno(2,3-c)isoquinolin-5-one
- Chemical Name: 4H-thieno[2,3-c]isoquinolin-5-one
- CAS Number: 420849-22-5
- Molecular Formula: C11H7NOS
- Molecular Weight: 201.244
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
- Create Date: 2017-01-05 18:40:09
- Modify Date: 2024-01-02 12:58:07
-
TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent[1].
| Name | 4H-thieno[2,3-c]isoquinolin-5-one |
|---|---|
| Synonyms |
MFCD06407947
TIQ-A Thieno[2,3-c]isoquinolin-5-one PARP Inhibitor X,TIQ-A Thieno[2,3-c]isoquinolin-5(4H)-one thieno(2,3-c)isoquinolin-5-one |
| Description | TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent[1]. |
|---|---|
| Related Catalog | |
| Target |
TNKS2:24 nM (IC50) PARP2:210 nM (IC50) PARP15:230 nM (IC50) PARP10:>10 μM (IC50) PARP14:>10 μM (IC50) |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 282.2±9.0 °C at 760 mmHg |
| Molecular Formula | C11H7NOS |
| Molecular Weight | 201.244 |
| Flash Point | 124.5±18.7 °C |
| Exact Mass | 201.024841 |
| PSA | 61.10000 |
| LogP | 3.16 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.675 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | R20/21/22 |
| RIDADR | NONH for all modes of transport |