thieno(2,3-c)isoquinolin-5-one
Modify Date: 2024-01-02 12:58:07
thieno(2,3-c)isoquinolin-5-one structure
|
Common Name | thieno(2,3-c)isoquinolin-5-one | ||
|---|---|---|---|---|
| CAS Number | 420849-22-5 | Molecular Weight | 201.244 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 282.2±9.0 °C at 760 mmHg | |
| Molecular Formula | C11H7NOS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 124.5±18.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of thieno(2,3-c)isoquinolin-5-oneTIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent[1]. |
| Name | 4H-thieno[2,3-c]isoquinolin-5-one |
|---|---|
| Synonym | More Synonyms |
| Description | TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent[1]. |
|---|---|
| Related Catalog | |
| Target |
TNKS2:24 nM (IC50) PARP2:210 nM (IC50) PARP15:230 nM (IC50) PARP10:>10 μM (IC50) PARP14:>10 μM (IC50) |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 282.2±9.0 °C at 760 mmHg |
| Molecular Formula | C11H7NOS |
| Molecular Weight | 201.244 |
| Flash Point | 124.5±18.7 °C |
| Exact Mass | 201.024841 |
| PSA | 61.10000 |
| LogP | 3.16 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.675 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | R20/21/22 |
| RIDADR | NONH for all modes of transport |
|
Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5.
J. Immunol. 177(9) , 6489-96, (2006) We recently used a murine model of allergic airway inflammation to show that poly(ADP-ribose) polymerase-1 (PARP-1) plays an important role in the pathogenesis of asthma-related lung inflammation. In ... |
|
|
Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content.
J. Pharmacol. Exp. Ther. 329(1) , 150-8, (2009) We recently showed that poly(ADP-ribose) polymerase (PARP) is activated within atherosclerotic plaques in an animal model of atherosclerosis. Pharmacological inhibition of PARP or reduced expression i... |
| MFCD06407947 |
| TIQ-A |
| Thieno[2,3-c]isoquinolin-5-one |
| PARP Inhibitor X,TIQ-A |
| Thieno[2,3-c]isoquinolin-5(4H)-one |
| thieno(2,3-c)isoquinolin-5-one |