1249398-09-1

1249398-09-1 structure

Name: Aza197
Chemical Name: AZA197
CAS Number: 1249398-09-1
Molecular Formula: C₂₄H₃₆N₆
Molecular Weight: 408.58
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-10-25 15:11:43
Modify Date: 2025-09-12 23:51:54
AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts[1].

Name	AZA197

Description	AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> PAK Signaling Pathways >> GPCR/G Protein >> Ras Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Cell Cycle/DNA Damage >> PAK Signaling Pathways >> Stem Cell/Wnt >> ERK
References	[1]. Zins K, et al. Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. J Transl Med. 2013 Nov 27;11:295.

Molecular Formula	C₂₄H₃₆N₆
Molecular Weight	408.58