2226735-54-0

2226735-54-0 structure

Name: RIP1 kinase inhibitor 8
Chemical Name: RIP1 kinase inhibitor 8
CAS Number: 2226735-54-0
Molecular Formula: C₁₈H₁₉F₂N₅O₂
Molecular Weight: 375.37
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2023-12-07 12:51:17
Modify Date: 2025-08-25 17:55:57
RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species[1].

Name	RIP1 kinase inhibitor 8

Description	RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species[1].
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Inflammation/Immunology
Target	IC50: 20 nM (RIP1)[1]
References	[1]. Harris PA, et al. Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J Med Chem. 2019 May 23;62(10):5096-5110.

Molecular Formula	C₁₈H₁₉F₂N₅O₂
Molecular Weight	375.37