RIP1 kinase inhibitor 8

Modify Date: 2025-08-25 17:55:57

RIP1 kinase inhibitor 8 structure	Common Name	RIP1 kinase inhibitor 8
	CAS Number	2226735-54-0	Molecular Weight	375.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₉F₂N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RIP1 kinase inhibitor 8

RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species[1].

Name	RIP1 kinase inhibitor 8

Description	RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species[1].
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Inflammation/Immunology
Target	IC50: 20 nM (RIP1)[1]
References	[1]. Harris PA, et al. Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J Med Chem. 2019 May 23;62(10):5096-5110.

Molecular Formula	C₁₈H₁₉F₂N₅O₂
Molecular Weight	375.37

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RIP1 kinase inhibitor 8

Use of RIP1 kinase inhibitor 8

Names

RIP1 kinase inhibitor 8 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.