45120-30-7

45120-30-7 structure

Name: H-Glu-OtBu
Chemical Name: (S)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid
CAS Number: 45120-30-7
Molecular Formula: C₉H₁₇NO₄
Molecular Weight: 203.236
Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative
Create Date: 2018-06-22 23:28:06
Modify Date: 2024-01-02 13:36:06
H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2

Name	(S)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid
Synonyms	L-Glutamic acid, 1-(1,1-dimethylethyl) ester L-Glutamic acid α-tert·butyl ester (4S)-4-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoic acid (4S)-4-Amino-5-tert-butoxy-5-oxopentanoic acid (non-preferred name) H-Glu-OtBu

Description	H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Hazard Codes	Xi
HS Code	2922509090

5891-45-2

~79%

45120-30-7

Literature: Eli Lilly and Company; COR Therapeutics Inc. Patent: US6291469 B1, 2001 ;

84793-07-7

45120-30-7

Literature: Gengrinovitch, Stela; Izakovich, Esther Patent: US2007/72800 A1, 2007 ; Location in patent: Page/Page column 13 ;

80165-23-7

45120-30-7

1676-73-9

45120-30-7

16874-06-9

56-86-0

2419-56-9

45120-30-7

Literature: Behrendt, L. Kirk Patent: US2004/30177 A1, 2004 ; Location in patent: Page 3 ;

32677-01-3

56-86-0

2419-56-9

45120-30-7

Literature: Behrendt, L. Kirk Patent: US2004/30177 A1, 2004 ; Location in patent: Page 3 ;

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%