DC Chemicals Limited
China
Product Name: RP106
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

496864-15-4

496864-15-4 structure

496864-15-4 structure

Name: RP106
Chemical Name: Aloisine RP106
CAS Number: 496864-15-4
Molecular Formula: C₁₆H₁₇N₃O
Molecular Weight: 267.32600
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2016-01-23 23:41:01
Modify Date: 2024-01-08 10:46:55
Aloisine RP106 (compound 38) is a potent inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 with IC50s of 0.70µM, 1.5µM, 0.92 µM, respectively[1].

Name	Aloisine RP106
Synonyms	7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine

Description	Aloisine RP106 (compound 38) is a potent inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 with IC50s of 0.70µM, 1.5µM, 0.92 µM, respectively[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	Cdk1/cyclin B:0.7 μM (IC50) Cdk5/p25:1.5 μM (IC50) GSK-3:0.92 μM (IC50)
References	[1]. Yvette Mettey, et al. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36.

Density	1.155g/cm3
Melting Point	182-184ºC
Molecular Formula	C₁₆H₁₇N₃O
Molecular Weight	267.32600
Exact Mass	267.13700
PSA	61.80000
LogP	3.67310
Index of Refraction	1.613

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335-H413
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
RIDADR	NONH for all modes of transport