RP106

Modify Date: 2024-01-08 10:46:55

RP106 Structure
RP106 structure
Common Name RP106
CAS Number 496864-15-4 Molecular Weight 267.32600
Density 1.155g/cm3 Boiling Point N/A
Molecular Formula C16H17N3O Melting Point 182-184ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of RP106


Aloisine RP106 (compound 38) is a potent inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 with IC50s of 0.70µM, 1.5µM, 0.92 µM, respectively[1].

 Names

Name Aloisine RP106
Synonym More Synonyms

 RP106 Biological Activity

Description Aloisine RP106 (compound 38) is a potent inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 with IC50s of 0.70µM, 1.5µM, 0.92 µM, respectively[1].
Related Catalog
Target

Cdk1/cyclin B:0.7 μM (IC50)

Cdk5/p25:1.5 μM (IC50)

GSK-3:0.92 μM (IC50)

References

[1]. Yvette Mettey, et al. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36.

 Chemical & Physical Properties

Density 1.155g/cm3
Melting Point 182-184ºC
Molecular Formula C16H17N3O
Molecular Weight 267.32600
Exact Mass 267.13700
PSA 61.80000
LogP 3.67310
Index of Refraction 1.613

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335-H413
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
RIDADR NONH for all modes of transport

 Synonyms

7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
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