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Related CAS#:
78966-69-5 85797-13-3
73952-11-1 1420043-66-8
7200-25-1 116797-51-4
6027-13-0 18760-80-0
3130-87-8 2074-53-5

85797-13-3

85797-13-3 structure
85797-13-3 structure
  • Name: DL-AP7
  • Chemical Name: 2-Amino-7-phosphonoheptanoic acid
  • CAS Number: 85797-13-3
  • Molecular Formula: C7H16NO5P
  • Molecular Weight: 225.17900
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
  • Create Date: 2016-08-20 11:26:21
  • Modify Date: 2024-01-02 18:56:32
  • DL-AP7 is a competitive NMDA antagonist and an anticonvulsant. DL-AP7 blocks the NMDA-induced convulsions and impairs learning performance in a passive avoidance task in mice[1].
Name 2-Amino-7-phosphonoheptanoic acid
Synonyms 2-amino-5-phosphonovaleric acid
acide amino-6 carboxy-6 hexylphosphonique
2-amino-5-phosphopentanoicacid
DL-APV
[3H]-DL-AP7
D-2-amino-5-phosphonovaleric acid
[3H]-DL-AP 5
DL-2-amino-5-phosphonovaleric acid
d-(+/-)-2-amino-5-phosphonopentanoic acid
5-PHOSPHONO-DL-NORVALINE
(-)2-amino-7-phosphonoheptanoic acid
AP-5
APV
2-amino-5-phosphovaleric acid
Description DL-AP7 is a competitive NMDA antagonist and an anticonvulsant. DL-AP7 blocks the NMDA-induced convulsions and impairs learning performance in a passive avoidance task in mice[1].
Related Catalog
In Vivo DL-AP7 (ICV) blocks the NMDA-induced convulsions (ED50=0.22 nmol/mouse) and impairs learning performance in a passive avoidance task in mice[1].
References

[1]. Chiamulera C, et al. Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning. Psychopharmacology (Berl). 1990;102(4):551-552.

Density 1.39g/cm3
Boiling Point 480.1ºC at 760mmHg
Molecular Formula C7H16NO5P
Molecular Weight 225.17900
Flash Point 244.2ºC
Exact Mass 225.07700
PSA 130.66000
LogP 0.83670

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MJ1927500
CHEMICAL NAME :
Heptanoic acid, 2-amino-7-phosphono-
CAS REGISTRY NUMBER :
85797-13-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H16-N-O5-P
MOLECULAR WEIGHT :
225.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 37,575,1985
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
RTECS MJ1927500
HS Code 2931900090
85685-91-2 structure

85685-91-2

~75%

85797-13-3 structure

85797-13-3
Literature: Aboujaoude, E. Elia; Collignon, N.; Savignac, P.; Bensoam, J. Phosphorus and Sulfur and the Related Elements, 1987 , vol. 34, p. 93 - 104
5183-26-6 structure

5183-26-6

~%

85797-13-3 structure

85797-13-3
Literature: Aboujaoude, E. Elia; Collignon, N.; Savignac, P.; Bensoam, J. Phosphorus and Sulfur and the Related Elements, 1987 , vol. 34, p. 93 - 104
137622-48-1 structure

137622-48-1

~%

85797-13-3 structure

85797-13-3
Literature: Ragulin, V. V.; Bofanova, M. E.; Tsvetkov, Eugene N. Phosphorus, Sulfur and Silicon and the Related Elements, 1991 , vol. 62, # 14 p. 237 - 242
111-24-0 structure

111-24-0

~%

85797-13-3 structure

85797-13-3
Literature: Aboujaoude, E. Elia; Collignon, N.; Savignac, P.; Bensoam, J. Phosphorus and Sulfur and the Related Elements, 1987 , vol. 34, p. 93 - 104
137622-51-6 structure

137622-51-6

~%

85797-13-3 structure

85797-13-3
Literature: Ragulin, V. V.; Bofanova, M. E.; Tsvetkov, Eugene N. Phosphorus, Sulfur and Silicon and the Related Elements, 1991 , vol. 62, # 14 p. 237 - 242
Precursor  3

DownStream  0

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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