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474713-20-7

474713-20-7 structure

474713-20-7 structure

Name: MK2-IN-5
Chemical Name: MK2-IN-5
CAS Number: 474713-20-7
Molecular Formula: C₆₁H₁₁₃N₂₁O₁₆
Molecular Weight: 1396.68
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2023-12-19 09:04:34
Modify Date: 2024-01-18 16:52:16
MK2-IN-5 is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation[1][2][3].

Name	MK2-IN-5

Description	MK2-IN-5 is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation[1][2][3].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> MAPKAPK2 (MK2) Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Others Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK1 ERK2
References	[1]. Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480. [2]. Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600. [3]. Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539.

Molecular Formula	C₆₁H₁₁₃N₂₁O₁₆
Molecular Weight	1396.68

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