225120-65-0

225120-65-0 structure

Name: Cathepsin Inhibitor 1
Chemical Name: 3-Chloro-N-(cyanomethyl)-Nα-{[1-methyl-3-(2-methyl-2-propanyl)-1H -pyrazol-5-yl]carbonyl}-L-phenylalaninamide
CAS Number: 225120-65-0
Molecular Formula: C₂₀H₂₄ClN₅O₂
Molecular Weight: 401.89000
Catalog: Biochemical Inhibitor Proteases Cysteine Protease Inhibitor
Create Date: 2018-09-19 20:56:53
Modify Date: 2026-07-21 15:45:36
Cathepsin inhibitor 1 (compound 25) is a potent and selective inhibitor of Cathepsin, with pIC50s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively[1].

Name	3-Chloro-N-(cyanomethyl)-Nα-{[1-methyl-3-(2-methyl-2-propanyl)-1H -pyrazol-5-yl]carbonyl}-L-phenylalaninamide
Synonyms	3-tert-butyl-N-{(1S)-1-(3-chlorobenzyl)-2-[(cyanomethyl)amino]-2-oxoethyl}-1-methyl-1H-pyrazole-5-cboxamide N-[(1S)-1-[(3-Chlorophenyl)methyl]-2-[(cyanomethyl)amino]-2-oxoethyl]-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-cboxamide Cathsin Inhibitor 1 Cathsin Inhibitor 1, 10 mM in DMSO 1H-Pyrazole-5-cboxamide, N-[(1S)-1-[(3-chlorophenyl)methyl]-2-[(cyanomethyl)amino]-2-oxoethyl]-3-(1,1-dimethylethyl)-1-methyl Cathsin,Inhibitor,CatK,CatB,CatL,Cathsin inhibitor-1,inhibit,Cathsin Inhibitor 1,CatL2,Cathsin inhibitor1,CatS

Description	Cathepsin inhibitor 1 (compound 25) is a potent and selective inhibitor of Cathepsin, with pIC50s of 7.9, 6.7, 6.0, 5.5 and 5.2 for CatL, CatL2, CatS, CatK, and CatB, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
References	[1]. Asaad N, et, al. Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4280-3.

HS Code	29242990