580-74-5
580-74-5 structure
- Name: Xantocillin
- Chemical Name: 1,4-Di-p-oxyphenyl-2,3-di-isonitrilo-1,3-butadiene
- CAS Number: 580-74-5
- Molecular Formula: C18H12N2O2
- Molecular Weight: 288.30
- Catalog: Signaling Pathways MAPK/ERK Pathway ERK
- Create Date: 2018-05-25 08:00:00
- Modify Date: 2024-01-03 21:23:01
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Xanthocillin is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway[1].
| Name | 1,4-Di-p-oxyphenyl-2,3-di-isonitrilo-1,3-butadiene |
|---|---|
| Synonyms |
XANTHOCILLINX
XANTHOCILINX Brevicide-x Ophthocillin 1,4-Bis-(4-hydroxy-phenyl)-2,3-diisocyan-buta-1,3-dien Xanthocillin Xantocillin 1,4-bis-(4-hydroxy-phenyl)-2,3-diisocyano-buta-1,3-diene Brevicid Brevicide Ethylene isocyanide,bis(p-hydroxybenzylidene) (1Z,3Z)-2,3-diisocyano-1,4-bis(4-hydroxyphenyl)buta-1,3-diene Trianthil |
| Description | Xanthocillin is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Xantocillin (SD118-xanthocillin X (1)) (6.9-55.56 µM; 48 hours) has a significant inhibitory effect on the proliferation of HepG2 cells with an IC50 of 22.88 ± 4.76 µM[1]. Xantocillin (SD118-xanthocillin X (1)) (24.3 µM; 12-48 hours) increases the expression of the autophagy-related genes, LC3, and Beclin 1[1]. Cell Proliferation Assay[1] Cell Line: HepG2 cells Concentration: 6.9 µM, 13.89 µM, 27.78 µM, 55.56 µM Incubation Time: 48 hours Result: A concentration-dependent inhibitory effect on cellular growth in the HepG2 cells with the IC50 of 22.88 ± 4.76 µM. Western Blot Analysis[1] Cell Line: HepG2 cells Concentration: 24.3 µM Incubation Time: 12 hours, 24 hours, 48 hours Result: Increased the expression of the autophagy-related genes, LC3, and Beclin 1. |
| References |
| Molecular Formula | C18H12N2O2 |
|---|---|
| Molecular Weight | 288.30 |
| Exact Mass | 288.09000 |
| PSA | 40.46000 |
| LogP | 2.77980 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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