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4792-15-8

4792-15-8 structure

4792-15-8 structure

Name: Pentaethylene glycol
Chemical Name: Pentaethylene glycol
CAS Number: 4792-15-8
Molecular Formula: C₁₀H₂₂O₆
Molecular Weight: 238.278
Catalog: Chemical reagent Organic reagent Fatty alcohol
Create Date: 2018-06-08 15:24:52
Modify Date: 2026-07-01 20:22:45
Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Pentaethylene glycol
Synonyms	Pentaethylene glycol (6CI, 7CI, 8CI) Pentaethylene gylcol MFCD00002878 3,6,9,12-tetraoxatetradocane-1,14-diol PENTAGLYCOL Pentaethylene glycol, 1,14-Dihydroxy-3,6,9,12-tetraoxatetradecane Pentaethylene glycol , PEG5 Pentaethylene glycol in methanol HO-PEG5-OH 3,6,9,12-Tetraoxatetradecane-1,14-diol, Pentaglycol 3,6,9,12-Tetraoxatetradecane-1,14-diol,Pentaglycol HO-5-OH PENTAETHYLENE GLYCOL PentaethyleneGlycol> OH-PEG5-OH DKSI125 EINECS 225-341-4 3,6,9,12-Tetraoxatetradecane-1,14-diol Pentaethylene Glycol PENTALETHYLENE ALYCOL PentaethyL 3,6,9,12-Tetraoxatetradecane-1,14-diol , Pentaethylene glycol pentaethyleneglycol 3,6,9,12-TETRAOXATETRADECANE-1,14-DIOL 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethanol Pentaethylene glycol, R

Description	Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.1±0.1 g/cm3
Boiling Point	356.1±32.0 °C at 760 mmHg
Molecular Formula	C₁₀H₂₂O₆
Molecular Weight	238.278
Flash Point	169.2±25.1 °C
Exact Mass	238.141632
PSA	77.38000
LogP	-2.59
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.458
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RZ2670000

CHEMICAL NAME :: Pentaethylene glycol

CAS REGISTRY NUMBER :: 4792-15-8

BEILSTEIN REFERENCE NO. :: 1635593

LAST UPDATED :: 199703

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H22-O6

MOLECULAR WEIGHT :: 238.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 22500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(12),77,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/m3/30D-I

TOXIC EFFECTS :: Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),86,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg/26W-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(12),77,1987

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RZ2670000
HS Code	2909499000

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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