676500-67-7

676500-67-7 structure

Name: Bevenopran
Chemical Name: 5-[2-methoxy-4-[[2-(oxan-4-yl)ethylamino]methyl]phenoxy]pyrazine-2-carboxamide
CAS Number: 676500-67-7
Molecular Formula: C₂₀H₂₆N₄O₄
Molecular Weight: 386.44500
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2017-06-09 15:58:53
Modify Date: 2024-01-12 19:17:01
Bevenopran is a peripheral μ-opioid receptor antagonist.

Name	5-[2-methoxy-4-[[2-(oxan-4-yl)ethylamino]methyl]phenoxy]pyrazine-2-carboxamide
Synonyms	UNII-IC58Q2EHPJ CB5945 Bevenopran

Description	Bevenopran is a peripheral μ-opioid receptor antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Inflammation/Immunology
Target	μ-opioid receptor[1]
In Vivo	Bevenopran is a peripheral μ-opioid receptor antagonist. Bevenopran is currently under investigation for the treatment of opioid-induced bowel dysfunction (OBD)[1]. Bevenopran tends to increase bowel movement (BM) frequency, especially for 0.1 mg twice daily and 4 mg daily, respectively[1].
References	[1]. Diego L, et al. Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs. 2011 Aug;20(8):1047-56. [2]. Siemens W, et al. Advances in pharmacotherapy for opioid-induced constipation - a systematic review. Expert Opin Pharmacother. 2015 Mar;16(4):515-32.