956014-19-0

956014-19-0 structure

Name: NS 11021
Chemical Name: Thiourea, N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
CAS Number: 956014-19-0
Molecular Formula: C₁₆H₉BrF₆N₆S
Molecular Weight: 511.24
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2017-04-30 12:53:42
Modify Date: 2024-01-07 20:53:05
NS 11021 is a potent and specific Ca2-activated big-conductance K＋ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].

Name	Thiourea, N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
Synonyms	1-[3,5-Bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(1H-tetrazol-5-yl)phenyl]thiourea NS 11021

Description	NS 11021 is a potent and specific Ca2-activated big-conductance K＋ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	Ca2＋-activated big-conductance K＋ Channels[1]
References	[1]. Bentzen BH，et al. The small molecule NS11021 is a potent and specific activator of Ca2⁺-activated big-conductance K⁺ channels. Mol Pharmacol. 2007 Oct;72(4):1033-44.