NS 11021

Modify Date: 2024-01-07 20:53:05

NS 11021 Structure
NS 11021 structure
Common Name NS 11021
CAS Number 956014-19-0 Molecular Weight 511.24
Density 1.798±0.06 g/cm3(20 °C , 760mmHg) Boiling Point 507.5±60.0 °C (760 mmHg)
Molecular Formula C16H9BrF6N6S Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of NS 11021


NS 11021 is a potent and specific Ca2-activated big-conductance K+ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].

 Names

Name Thiourea, N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
Synonym More Synonyms

 NS 11021 Biological Activity

Description NS 11021 is a potent and specific Ca2-activated big-conductance K+ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].
Related Catalog
Target

Ca2+-activated big-conductance K+ Channels[1]

References

[1]. Bentzen BH,et al. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol. 2007 Oct;72(4):1033-44.

 Chemical & Physical Properties

Density 1.798±0.06 g/cm3(20 °C , 760mmHg)
Boiling Point 507.5±60.0 °C (760 mmHg)
Molecular Formula C16H9BrF6N6S
Molecular Weight 511.24
Exact Mass 509.97000
PSA 110.61000
LogP 5.62170

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H413
Precautionary Statements P301 + P310
RIDADR UN 2811 6.1 / PGIII

 Synonyms

1-[3,5-Bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(1H-tetrazol-5-yl)phenyl]thiourea
NS 11021
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