77128-69-9
77128-69-9 structure
- Name: (Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)
- Chemical Name: G Substance P (5-11)
- CAS Number: 77128-69-9
- Molecular Formula: C43H61N9O9S
- Molecular Weight: 880.064
- Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
- Create Date: 2018-12-29 20:32:25
- Modify Date: 2025-08-22 22:07:09
-
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats[1][2][3].
| Name | G Substance P (5-11) |
|---|---|
| Synonyms |
5-Oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl-L-methioninamide
PGLU5,MEPHE8,SAR9-SUBSTANCE P FRAGMENT*5-11 PGLU-GLN-PHE-N-METHYL-PHE-SAR-LEU-MET-NH2 DiMe-C7 PYR-GLN-PHE-N-ME-PHE-SAR-LEU-MET-NH2 SUBSTANCE P (PGLU5,MEPHE8,SAR9)-*FRAGMEN T 5-11 L-Methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl- [GLP5,(ME)PHE8,SAR9] SUBSTANCE P (5-11) GLP-GLN-PHE-(NME)PHE-SAR-LEU-MET-NH2 [pGlu5,MePhe8,Sar9]substance P(5-11) (PYR5,N-ME-PHE8,SAR9)-SUBSTANCE P (5-11) substance P (5-11),pGlu(5)-MePhe(8)-MeGly(9) |
| Description | [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vivo | [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (2 µg/side; inject into the ventral tegmental area; single) 选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢[1]。 [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 µg/side; inject into the ventral tegmental area; single) 增加大鼠运动活性，诱导可卡因寻求行为的恢复[2]。 Animal Model: Male Sprague-Dawley rats (300-350 g)[1]. Dosage: 2 µg/side Administration: Inject into the ventral tegmental area; single Result: Selectively activated mesolimbic and mesocortical dopamine metabolism. Animal Model: Male Wistar rats (300-350 g)[2]. Dosage: 0.5, 1.5, 3 µg/side Administration: Inject into the ventral tegmental area; single Result: Significantly increased locomotor activity when at 3 µg/side. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1291.2±65.0 °C at 760 mmHg |
| Molecular Formula | C43H61N9O9S |
| Molecular Weight | 880.064 |
| Flash Point | 734.7±34.3 °C |
| Exact Mass | 879.431274 |
| PSA | 297.60000 |
| LogP | 1.66 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.580 |