(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)
Modify Date: 2025-08-22 22:07:09
(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11) structure
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Common Name | (Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11) | ||
|---|---|---|---|---|
| CAS Number | 77128-69-9 | Molecular Weight | 880.064 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1291.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C43H61N9O9S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 734.7±34.3 °C | |
Use of (Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats[1][2][3]. |
| Name | G Substance P (5-11) |
|---|---|
| Synonym | More Synonyms |
| Description | [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats[1][2][3]. |
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| Related Catalog | |
| In Vivo | [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (2 µg/side; inject into the ventral tegmental area; single) 选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢[1]。 [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 µg/side; inject into the ventral tegmental area; single) 增加大鼠运动活性，诱导可卡因寻求行为的恢复[2]。 Animal Model: Male Sprague-Dawley rats (300-350 g)[1]. Dosage: 2 µg/side Administration: Inject into the ventral tegmental area; single Result: Selectively activated mesolimbic and mesocortical dopamine metabolism. Animal Model: Male Wistar rats (300-350 g)[2]. Dosage: 0.5, 1.5, 3 µg/side Administration: Inject into the ventral tegmental area; single Result: Significantly increased locomotor activity when at 3 µg/side. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1291.2±65.0 °C at 760 mmHg |
| Molecular Formula | C43H61N9O9S |
| Molecular Weight | 880.064 |
| Flash Point | 734.7±34.3 °C |
| Exact Mass | 879.431274 |
| PSA | 297.60000 |
| LogP | 1.66 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.580 |
| 5-Oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl-L-methioninamide |
| PGLU5,MEPHE8,SAR9-SUBSTANCE P FRAGMENT*5-11 |
| PGLU-GLN-PHE-N-METHYL-PHE-SAR-LEU-MET-NH2 |
| DiMe-C7 |
| PYR-GLN-PHE-N-ME-PHE-SAR-LEU-MET-NH2 |
| SUBSTANCE P (PGLU5,MEPHE8,SAR9)-*FRAGMEN T 5-11 |
| L-Methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl- |
| [GLP5,(ME)PHE8,SAR9] SUBSTANCE P (5-11) |
| GLP-GLN-PHE-(NME)PHE-SAR-LEU-MET-NH2 |
| [pGlu5,MePhe8,Sar9]substance P(5-11) |
| (PYR5,N-ME-PHE8,SAR9)-SUBSTANCE P (5-11) |
| substance P (5-11),pGlu(5)-MePhe(8)-MeGly(9) |