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4330-99-8

4330-99-8 structure
4330-99-8 structure
  • Name: Alimemazine hemitartrate
  • Chemical Name: Alimemazine hemitartrate
  • CAS Number: 4330-99-8
  • Molecular Formula: C18H22N2S.1/2C4H6O6
  • Molecular Weight: 373.49
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2018-02-20 08:00:00
  • Modify Date: 2025-08-25 11:42:25
  • Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.
Name Alimemazine hemitartrate
Synonyms Trimeprazine Tartrate
10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine Tartrate
10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, 2,3-dihydroxybutanedioate (1:1) (salt)
Alimemazine
EINECS 224-368-9
N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine 2,3-dihydroxybutanedioate (1:1)
N,N,2-Trimethyl-3-(10H-phenothiazin-10-yl)-1-propanamine 2,3-dihydroxysuccinate (1:1)
MFCD00242594
Description Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.
Related Catalog
Target

HA receptor[1]

References

[1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64.

Melting Point >300 °C(lit.)
Molecular Formula C18H22N2S.1/2C4H6O6
Molecular Weight 373.49
PSA 178.62000
LogP 6.98140
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SO6475000
CAS REGISTRY NUMBER :
4330-99-8
LAST UPDATED :
199504
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C36-H44-N4-S2.C4-H6-O6
MOLECULAR WEIGHT :
747.06
WISWESSER LINE NOTATION :
T C666 BN ISJ B1Y1&1N1&1 &OVYQYQVO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,41,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5558 No. of Facilities: 137 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1472 (estimated) No. of Female Employees: 835 (estimated)
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements Missing Phrase - N15.00950417
Hazard Codes Xn
Risk Phrases 20/21/22
Safety Phrases S36
RIDADR 3249
RTECS SO6475000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2934300000
HS Code 2934300000
Summary 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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