Alimemazine hemitartrate

Modify Date: 2025-08-25 11:42:25

Alimemazine hemitartrate structure	Common Name	Alimemazine hemitartrate
	CAS Number	4330-99-8	Molecular Weight	373.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₂N₂S_.1/₂C₄H₆O₆	Melting Point	>300 °C(lit.)
	MSDS	N/A	Flash Point	N/A
	Symbol	GHS06	Signal Word	Danger

Use of Alimemazine hemitartrate

Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.

Name	Alimemazine hemitartrate
Synonym	More Synonyms

Description	Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Research Areas >> Inflammation/Immunology
Target	HA receptor[1]
References	[1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64.

Melting Point	>300 °C(lit.)
Molecular Formula	C₁₈H₂₂N₂S_.1/₂C₄H₆O₆
Molecular Weight	373.49
PSA	178.62000
LogP	6.98140
Storage condition	Refrigerator

Alimemazine hemitartrate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO6475000

CAS REGISTRY NUMBER :: 4330-99-8

LAST UPDATED :: 199504

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C36-H44-N4-S2.C4-H6-O6

MOLECULAR WEIGHT :: 747.06

WISWESSER LINE NOTATION :: T C666 BN ISJ B1Y1&1N1&1 &OVYQYQVO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,41,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5558 No. of Facilities: 137 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1472 (estimated) No. of Female Employees: 835 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	Missing Phrase - N15.00950417
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	S36
RIDADR	3249
RTECS	SO6475000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2934300000

HS Code	2934300000
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Alterations in intracranial pressure following ketamine anesthesia in hydrocephalic children.

Indian J. Pediatr. 51(408) , 25-8, (1984)

Pruritus in burns. Comments from the Vancouver General Hospital Burn Unit, Vancouver, British Columbia.

J. Burn Care Rehabil. 9(3) , 310-1, (1988)

Behavioural changes in children following minor surgery--is premedication beneficial?

Acta Anaesthesiol. Belg. 43(3) , 173-9, (1992)

One hundred and twenty-three male children, aged one to ten years, were studied to determine the influence of premedication on changes in patterns of behaviour following hospitalization for repair of ...

Trimeprazine Tartrate

10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine Tartrate

10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, 2,3-dihydroxybutanedioate (1:1) (salt)

Alimemazine

EINECS 224-368-9

N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine 2,3-dihydroxybutanedioate (1:1)

N,N,2-Trimethyl-3-(10H-phenothiazin-10-yl)-1-propanamine 2,3-dihydroxysuccinate (1:1)

MFCD00242594

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Alimemazine hemitartrate

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